Table 1.
Differentially expressed genes (DEGs) in MDA-MB-231/IR cells related to cancer resistance. DEGs are expressed in differences, fold changes (log2), with their functions.
| No. | Difference | Fold | Gene | Full Name | Role in Cancer |
|---|---|---|---|---|---|
| 1 | 97.57 | 6.83 | AKR1C1 | Aldo-keto reductase 1C1 | Metastasis |
| 2 | 79.67 | 6.64 | FTL | Ferritin light chain | Drug resistance |
| 3 | 77.43 | 2.92 | MK | Midkine | Metastasis |
| 4 | 62.20 | 6.01 | LG3BP | Galectin-3-binding protein | Anti-differentiation |
| 5 | 46.92 | 3.04 | GFPT2 | Glutamine-fructose-6-phosphate Transaminase 2 | Metabolism |
| 6 | 42.64 | 3.34 | TGFBI | Transforming growth factor beta induced | Metastasis |
| 7 | 42.35 | 3.87 | AKR1C3 | Aldo-keto reductase 1C3 | Drug resistance |
| 8 | 37.59 | 2.96 | CCDC69 | Coiled-coil domain-containing 69 | Drug resistance |
| 9 | 14.51 | 4.13 | AKR1C2 | Aldo-keto reductase 1C2 | Metastasis |
| 10 | 12.55 | +Inf | TWF1 | Twinfilin actin binding protein 1 | Migration |
| 11 | −4.33 | −Inf | PKP3 | Plakophilin 3 | Invasion |
| 12 | −85.90 | −2.84 | IFIT2 | Interferon induced protein with tetratricopeptide repeats 2 | Apoptosis mediator |
Inf, infinity: expression of the indicated gene was not determined.