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. 2019 Mar 16;20(6):1341. doi: 10.3390/ijms20061341

Figure 3.

Figure 3

Gustatory nerve responses from innervation to anterior and posterior tongue taste buds. Whole nerve recordings from the chorda tympani nerve (CT) innervating taste buds in the anterior tongue and the glossopharyngeal nerve (GL) innervating taste buds in the circumvallate papilla and surrounding tissue of the posterior tongue. Responses to chemical, cold water (4 °C), and tactile stroking stimuli were recorded in Vehicle- and Sonidegib-treated rodents and for the CT after 14 days recovery from Sonidegib treatment. After Hh pathway inhibition with Sonidegib the responses to chemical stimuli were eliminated (CT) or substantially reduced (GL). However, responses to cold and tactile stimuli were maintained, indicating a modality-specific role for the Hh pathway in lingual sensory function. In recordings from the CT after 14 days recovery from Sonidegib treatment, responses to taste stimuli returned in concert with taste bud recovery [6,7]. Recording images for Anterior tongue/CT are extracted from Figure 8 in Kumari et al. 2017 [6] with permission, and for Posterior tongue/GL are extracted from Figure 6 in Kumari et al. 2018 [7] with permission.