Figure 4.

Schematic representation of cell-specific effects of c-Jun on apoE gene expression. In macrophages, c-Jun binding to the apoE core promoter downregulated apoE expression, in conjunction with other transcription factors. ME.2 distal regulatory element was brought into the proximity of the apoE promoter, and the functional AP-1 binding site on ME.2 additionally potentiated c-Jun repression of apoE (left side). In hepatocytes, the HCR-1 distal regulatory element interacted with the apoE promoter, but apoE expression was upregulated by c-Jun in a classical manner through binding to a canonical binding site located at −94/−84 in the apoE proximal promoter, (right side). AP-1 sites are illustrated as purple circles.