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. 2019 Mar 14;20(6):1286. doi: 10.3390/ijms20061286

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Anti-tumor effect of adenosine (ADE) in a xenograft NOD/SCID mouse bearing EBVaGC (MKN1-EBV). (A) A schematic diagram of the xenograft mouse model antitumor assay. DW group (n = 6) and ADE (30 mg/kg) group (n = 6); (B) Weight measurement of mice bearing MKN1-EBV cell-derived tumors during a whole experimental period; (C) Representative image of a NOD/SCID mouse bearing MKN1-EBV cells-derived tumors; (D) Determination of the antitumor effects of adenosine on the development of MKN1-EBV cells-derived tumors in NOD/SCID mice. Image of xenograft mouse model after three weeks from oral administration; (E) Confirmation of adenosine-derived BZLF1 induction in MKN1-EBV cells-derived tumors in NOD/SCID mice. ADE and DW = adenosine and drinking water, respectively.

Anti-tumor effect of adenosine (ADE) in a xenograft NOD/SCID mouse bearing EBVaGC (MKN1-EBV). (A) A schematic diagram of the xenograft mouse model antitumor assay. DW group (n = 6) and ADE (30 mg/kg) group (n = 6); (B) Weight measurement of mice bearing MKN1-EBV cell-derived tumors during a whole experimental period; (C) Representative image of a NOD/SCID mouse bearing MKN1-EBV cells-derived tumors; (D) Determination of the antitumor effects of adenosine on the development of MKN1-EBV cells-derived tumors in NOD/SCID mice. Image of xenograft mouse model after three weeks from oral administration; (E) Confirmation of adenosine-derived BZLF1 induction in MKN1-EBV cells-derived tumors in NOD/SCID mice. ADE and DW = adenosine and drinking water, respectively.