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. 2019 Mar 15;11(3):122. doi: 10.3390/pharmaceutics11030122
DKT dexketoprofen trometamol
DK dexketoprofen
FaSSIF-v1 fasted state simulated intestinal fluids version 1
SGF simulated gastric fluids
HPLC high-performance liquid chromatography
LLPS liquid–liquid phase separation
PK pharmacokinetics
GIS gastrointestinal simulator
USP United States Pharmacopeia
GI gastrointestinal
BE bioequivalence
AUC area under the curve
Cmax maximal concentration
CH high concentration of DKT
CL low concentration of DKT
IVIVC in vitro–in vivo correlation
REF reference listed drug product
Non-BE non-bioequivalent
Ssalt Solubility of the salt form of dexketoprofen (i.e., dexketoprofen trometamol)
Sacid Solubility of the salt form of dexketoprofen
NaCl sodium chloride
S0 intrinsic solubility of dexketoprofen
pHmax the pHmax refers to the pH where both the DKT and free acid have equal solubilities.
Ksp salt solubility product
TH+ positively ionized trometamol
GISstomach gastrointestinal simulator gastric chamber
GISduodenum gastrointestinal simulator duodenal chamber
GISjejunum gastrointestinal simulator jejunal chamber
Fa fraction absorbed
HA acid form
A negative ionized acid form
BH protonated basic form
RE% relative prediction error in percentage
EMA European Medicines Agency
BCS biopharmaceutics classification system
NaOH sodium hydroxide
HCl hydrochloric acid
TFA trifluoracetic acid