Table 2.

The 49 positions with significant rate shifts between the c-Myc and N-Myc subfamilies

Rank	Position in human c-Myc	Slower subfamily	Significance	Bayesian rank	Rank	Position in human c-Myc	Slower subfamily	Significance	Bayesian rank	Rank	Position in human c-Myc	Slower subfamily	Significance	Bayesian rank
1	94	c-Myc	0.000040	—	18	284	N-Myc	0.010	4	35	146	c-Myc	0.027	11
2	221	c-Myc	0.00054	—	19	230	c-Myc	0.012	12	36	285	N-Myc	0.028	16
3	96	c-Myc	0.00062	—	20	157	c-Myc	0.012	—	37	153	c-Myc	0.031	—
4	272	N-Myc	0.00081	—	21	117	c-Myc	0.013	—	38	408	N-Myc	0.031	15
5	113	c-Myc	0.00085	2	22	283	N-Myc	0.014	6	39	121	c-Myc	0.035	13
6	68	c-Myc	0.0020	—	23	111	c-Myc	0.014	39	40	150	c-Myc	0.035	41
7	99	c-Myc	0.0025	1	24	277	N-Myc	0.015	3	41	83	c-Myc	0.036	—
8	114	c-Myc	0.0030	—	25	154	c-Myc	0.015	80	42	73	c-Myc	0.037	—
9	286	N-Myc	0.0040	—	26	293	c-Myc	0.017	10	43	282	N-Myc	0.037	24
10	66	c-Myc	0.0044	—	27	222	c-Myc	0.017	—	44	340	c-Myc	0.040	17
11	178	c-Myc	0.0071	—	28	301	c-Myc	0.017	9	45	404	N-Myc	0.041	21
12	273	N-Myc	0.0072	—	29	100	c-Myc	0.018	19	46	281	N-Myc	0.043	8
13	75	c-Myc	0.0077	—	30	122	c-Myc	0.022	14	47	414	N-Myc	0.048	5
14	69	c-Myc	0.0082	—	31	214	N-Myc	0.023	—	48	67	c-Myc	0.049	—
15	274	N-Myc	0.0084	30	32	109	c-Myc	0.024	18	49	93	c-Myc	0.050	—
16	116	c-Myc	0.0091	—	33	314	c-Myc	0.026	47
17	70	c-Myc	0.0099	—	34	115	c-Myc	0.027	—

These 49 positions are ranked according to their P values. At a significance level of 0.05, approximately 22 significant sites are expected by chance. Thus, approximately 22 of these sites may be random occurrences. Bayesian rank refers to the results from the Bayesian analysis of these Myc sequences (15). As this method cannot accommodate sites with any gaps or unknown positions, several sites in our analysis (marked by dashes) were excluded by the former.