Table 2.

List of 50 genes where causative or probably causative variants were reported to cause early-onset dementia.

Disease Categories	No. of Genes	Candidate Genes Selection
Alzheimer’s disease	19	APP, PSEN1, PSEN2, S100A9, CR1, BIN1, TREM2, CLU, CTNNA3, DNMBP, SORL1, BACE1, PICALM, GAB2, LPR6, ADAM10, ABCA7, CD33, TOMM40.
Amyotrophic Lateral Sclerosis (ALS)and Frontotemporal dementia (FTD)	18	TDP43, CHMP2B, SIGMAR1, VCP, FUS, GRN, MAPT, UBQLN2, ALS2, TAF15, FIG4, OPTN, DAO, HNRNPA1, SOD1, ANG, VAPB, SQSTM1.
Dementia with Lewy Bodies	7	PINK1, PARK7, PARK9, GBA, SNCA, PARK2, LRRK2.
Other neurodegenerative	6	SPAST, CYP7B1, SPG11, CSF1R, NOTCH3, PRNP.