Skip to main content
. 2019 Mar 25;20(6):1489. doi: 10.3390/ijms20061489

Figure 1.

Figure 1

PRGF increased cell-based BBB tightness in-vitro. (A) Concentration-dependent decrease in LY permeation (PC) across the bEnd-3 cells-based BBB model. Data represented as mean ± SD of 3 independent experiments with n = 4 wells/treatment/experiment. (B) Representative blots and densitometry analysis of tight junction proteins demonstrated a concentration-dependent increase of ZO1, occludin, and claudin-5. Data are presented as mean ± SD of three independent experiments with n = 3 dishes/treatment group/experiment. * p < 0.05, *** p < 0.001 compared to control (CTRL) group. # p < 0.05, ## p < 0.01, and ### p < 0.001 compared to PRGF 10% dilution.