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Effect of VEGF (100 pg/mL) and PRGF (100%) on Aβ brain levels in 5xFAD mice. (A) VEGF and PRGF enhanced the BEI % of exogenously administered 125I-Aβ40 across the BBB of 5xFAD mice brains. (B) The treatment with PRGF increased the total Aβ40 and Aβ42 levels, while VEGF had no effect on Aβ brain levels in mice brains as measured by ELISA. Data are presented as mean ± SEM (n = 7 mice/group). * p < 0.05, *** p < 0.001 compared to control (CTRL) group.
