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. 2019 Mar 16;20(6):1334. doi: 10.3390/ijms20061334

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Workflow with the summarized study design and main results. (A) In the previous study [20], we developed a 21-CpG (5-cytosine-phosphate-guanine-3) prognostic classifier, presenting a high performance in discriminating WDTC-PP from WDTC-GP. (B) In the current study, we evaluated three CpGs from the previous classifier and tested the prognostic potential in array-dependent and independent WDTC samples. This analysis revealed PFKFB2 hypomethylation as an independent poor prognostic factor. WDTC: well-differentiated thyroid carcinomas; PP: poor prognosis; GP: good prognosis; Δβ: delta of the mean methylation values (beta) from PP and GP cases; DLDA: Diagonal Linear Discriminant Analysis; BIS-PYRO: bisulfite pyrosequencing; ↑: high; ↓: low; * PTC patients from The Cancer Genome Atlas (TCGA) cohort elected based on the inclusion criteria [20]; ^# selection of three probes confirmed by TCGA (Δβ > |0.1|) presenting high AUC in the internal microarray data; r: correlation coefficient; methyl: methylation.