Table 2.
Hematologic parameters in rats treated with copper sources by oral administration over 28 consecutive days.
| Index | Control | Micro-Cu | CuCl2·2H2O | Nano-Cu 80–100 nm | ||
|---|---|---|---|---|---|---|
| 1%HPMC | 200 (mg/kg) | 200 (mg/kg) | 50 (mg/kg) | 100 (mg/kg) | 200 (mg/kg) | |
| RBC (1012/L) | 7.8 ± 0.5 | 7.2 ± 0.4 | 7.2 ± 0.3 | 7.1 ± 0.3 | 6.9 ± 0.4 * | 6.7 ± 0.5 * |
| WBC (109/L) | 9.2 ± 2.5 | 13.5 ± 2.6 ** | 17.1 ± 3.5 ** | 10.1 ± 2.5 | 10.9 ± 2.1 * | 12.9 ± 2.3 ** |
| lymphocytes (%) | 8.8 ± 2.7 | 11.6 ± 3.4 ** | 12.7 ± 3.1 ** | 8.4 ± 1.6 | 9.5 ± 1.4 | 10.9 ± 2.3 ** |
| PLT (109/L) | 1337.6 ± 100.5 | 1395 ± 104.6 | 1292.1 ± 135.4 | 1368.6 ± 100.6 | 1393.7 ± 65.1 | 1424.2 ± 129.9 * |
| HGB (g/dL) | 159.3 ± 5.3 | 155 ± 8.1 | 155.1 ± 6.7 | 154.9 ± 9.9 | 156.7 ± 4.5 | 155.6 ± 12.3 |
| HCT (%) | 46 ± 2.8 | 42.8 ± 2.4 | 42.7 ± 2 | 48.6 ± 2.6 | 40.7 ± 1.3 * | 40.9 ± 2.6 * |
* p < 0.05 and ** p < 0.01 vs. Control. Values represent means ± SD (N = 10).