Table 1.

Review of medical-grade polyurethane systems in which polycaprolactone (PCL) is used as a polyol part of the chain.

Polyurethane System	Short Description	Year	Reference
(SF/LDI/PCLdiol/BDA) Silk fibroin poly(ester-urethane) urea	Tissue scaffolds with the structure of nanofibers for the regeneration of the heart valves obtained via electrospinning.	2018	[18]
(HDI/PCLtriol/PEG/glycerol) Crosslinked aliphatic poly(ester urethane)	Biodegradable polyurethane films with cross-linked hydrolysable bonds and a homogeneous structure for biomedical applications. PU with hydrogel behavior and susceptibility to hydrolytic degradation.	2015	[19]
(LDI-ε-caprolactone)block/LDI) Polyurethane block copolymer	Biodegradable PU with potential application in soft tissue engineering. A synthesis of a poly (L-lactide-ε-caprolactone) block copolymer was carried out, which was then used to react with L-lysine diisocyanate(LDI). The PU obtained can be used as a viscous injection which is cured in situ.	2017	[20]
(BDI/PCLdiol/L-Lysine ethyl ester dihydrochloride) Poly(ester-urethane)	Poly(ester-urethane) tissue scaffolds were obtained using the melt-extrusion additive manufacturing technique. The obtained scaffolds were cytocompatible and tested for use in the regeneration of myocardial tissue.	2014	[21]
(HDI/PCLdiol/BDO/Fe2O3 nanoparticles) Magnetic poly(ester-urethane) nanocmposite	A poly(ester-urethane) material of potential application for the regeneration of nerve tissue was obtained. The addition of nanoparticles improved the electrical conductivity, hydrophilicity and roughness of the obtained material. Biological tests show that nanocomposite was biocompatible and has suitable cell viability (in vitro cytotoxicity).	2014	[22]
(HDI/PCLdiol/PEG) Aliphatic poly(ester-urethane)	Electrospunednanofiberpoly(ester-urethane) membranes dedicated for guided bone regeneration. Obtained membranes had mechanical properties slightly higher than commercially available collagen or PTFE membrane.	2018	[23]