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. 2019 Mar 18;19(5):3505–3518. doi: 10.3892/mmr.2019.10051

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effects of TGF-β1 and inhibition of the PI3K/AKT pathway on the expression of osteogenic and migration-associated genes. Expression of osteogenic (OCN, OPN, Osterix and RUNX2) and migration-associated (MMP2 and MMP9) genes following treatment for 14 days with 1 ng/ml TGF-β1 and/or 10 µM LY, a PI3K/AKT inhibitor, as determined by reverse transcription-quantitative polymerase chain reaction. Data are presented as the mean ± standard deviation. **P<0.01, ***P<0.001 vs. NC. AKT, protein kinase B; LY, LY294002; MMP, matrix metalloproteinase; NC, negative control; OCN, osteocalcin; OPN, osteopontin; Osterix, transcription factor Sp7; PI3K, phosphatidylinositol 3-kinase; RUNX2, Runt-related transcription factor 2; TGF-β1, transforming growth factor β1.