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. 2019 Mar 19;10(3):235. doi: 10.3390/genes10030235

Figure 1.

Figure 1

Schematic of cystic fibrosis transmembrane conductance regulator (CFTR) topologically associated domain (TAD) in airway and intestinal cell types.CFTR promoter (blue arrow) and gene are shown. TAD boundaries are denoted as “I” (−80.1 kb) and “II” (+48.9 kb). Occupancy of CCCTC-binding factor (CTCF) at the TAD boundaries is shown as red circles. Cohesin complex is shown as gray rings. (A) Airway-selective enhancer elements at −44 kb and −35 kb are shown by dark and light blue boxes, respectively. (B) Intestine-selective enhancer elements at 185 + 10kb (intron 1) and 1811 + 0.8kb (intron 11) are shown by dark and light gray boxes, respectively. Figures are not drawn to scale.