Table 3.
Basic association testing for 39 genotyped SNPs showing minor allele frequencies (MAFs), Hardy-Weinberg Equilibrium (HWE) score for controls, unadjusted odds ratios, and p-values and adjusted p-values after correction for multiple testing. A1, minor allele; A2, major allele; MAF, minor allele frequency; NCHROBS, number of chromosomes observed; 1000G, 1000 Genomes Database; HWE, Hardy-Weinberg Equilibrium; OR, odds ratio.
| Chr | miRNA/Target Gene | SNP | A1 | A2 | MAF/NCHROBS | MAF 1000G | HWEUNAFF | OR | p-Value | Adjusted p-Value |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | E2F2 | rs2075993 | G | A | 0.5/862 | G = 0.3488/1747 | 0.2368 | 0.885 | 0.4535 | 1 |
| 1 | GEMIN3 3′-UTR | rs197412 | C | T | 0.4092/870 | C = 0.4744/2376 | 0.6013 | 0.8779 | 0.4301 | 1 |
| 2 | hsa-miR-155-3p | rs4672612 | A | G | 0.338/858 | A = 0.3878/1942 | 0.5476 | 1.095 | 0.6006 | 1 |
| 4 | TET2 | rs7670522 | A* | C | 0.4701/870 | C = 0.3600/1803 | 1.000 | 1.089 | 0.6041 | 1 |
| 4 | hsa-miR-4330/5100 | rs2647257 | T | A | 0.408/848 | T = 0.2386/1195 | 0.3732 | 0.9403 | 0.7094 | 1 |
| 5 | hsa-miR-224-5p | rs12719481 | G | A | 0.2719/868 | G = 0.3670/1838 | 1.000 | 1.072 | 0.7052 | 1 |
| 5 | hsa-miR-143 | rs3733846 | G | A | 0.1367/878 | G = 0.2063/1033 | 1.000 | 0.5646 | 0.012 | 0.467 |
| 5 | hsa-miR-143 | rs17723799 | T | C | 0.1129/868 | T = 0.1118/560 | 1.000 | 0.423 | 0.0004 | 0.015 |
| 5 | hsa-miR-143 | rs41291957 | A | G | 0.1412/878 | A = 0.1214/608 | 1.000 | 0.5624 | 0.008 | 0.326 |
| 5 | hsa-miR-145 | rs353291 | C | T | 0.4237/826 | C = 0.3608/1807 | 0.1473 | 1.204 | 0.2648 | 1 |
| 5 | hsa-miR-146-a | rs2910164 | C | G | 0.2204/862 | C = 0.2797/2881 | 0.5978 | 1.19 | 0.3908 | 1 |
| 5 | hsa-miR-218-2 | rs11134527 | A | G | 0.2189/868 | A = 0.3462/1734 | 0.7982 | 1.061 | 0.7635 | 1 |
| 6 | XPO5 | rs11077 | G | T | 0.4255/872 | G = 0.4036/2021 | 0.3862 | 0.9566 | 0.7869 | 1 |
| 6 | TAB2 | rs9485372 | A | G | 0.1965/850 | A = 0.2408/1206 | 1.000 | 0.844 | 0.4084 | 1 |
| 6 | ESR1, C6orf97 | rs2046210 | A | G | 0.3353/850 | A = 0.4121/2064 | 1.000 | 1.277 | 0.1659 | 1 |
| 8 | TP53 | rs896849 | G | A | 0.1501/866 | G = 0.2183/1093 | 0.4915 | 0.9369 | 0.7695 | 1 |
| 8 | CASC21 | rs13281615 | G | A | 0.4417/840 | G = 0.4912/2460 | 0.3853 | 0.7541 | 0.08388 | 1 |
| 8 | AGO2 | rs3864659 | C | A | 0.1023/860 | C = 0.1436/719 | 0.6026 | 1.147 | 0.6275 | 1 |
| 8 | AGO2 | rs4961280 | A | C | 0.1835/872 | A = 0.1490/746 | 0.7390 | 1.416 | 0.1075 | 1 |
| 9 | hsa-miR-101-2 | rs462480 | G | T | 0.3984/876 | G = 0.4451/2229 | 0.7246 | 1.001 | 0.9948 | 1 |
| 10 | hsa-miR-608 | rs4919510 | G | C | 0.1979/874 | G = 0.3638/1822 | 1.000 | 1.115 | 0.6034 | 1 |
| 10 | hsa-miR-202 | rs12355840 | C | T | 0.1368/848 | C = 0.3189/1597 | 0.6598 | 0.494 | 0.1049 | 1 |
| 11 | hsa-miR-210 | rs1062099 | C | G | 0.1701/876 | C = 0.1649/826 | 0.3067 | 1.29 | 0.2536 | 1 |
| 11 | LSP1 | rs3817198 | C | T | 0.3289/836 | C = 0.2155/1079 | 0.7152 | 0.7085 | 0.04181 | 1 |
| 11 | TMEM45, BARX2 | rs7107217 | A | C | 0.4883/858 | A = 0.4876/2442 | 0.5987 | 0.8992 | 0.514 | 1 |
| 12 | KRAS 3′-UTR | rs61764370 | C | A | 0.0962/852 | C = 0.0347/174 | 1.000 | 0.6795 | 0.1473 | 1 |
| 12 | hsa-miR-196-a2 | rs11614913 | T | C | 0.4205/880 | T = 0.333/1666 | 0.226 | 0.928 | 0.6501 | 1 |
| 12 | pre-miR-618 | rs2682818 | A | C | 0.1465/874 | A = 0.2424/1214 | 0.3061 | 1.115 | 0.6448 | 1 |
| 14 | HIF1A 3′-UTR | rs2057482 | T | C | 0.1250/856 | T = 0.2424/1214 | 0.6797 | 1.106 | 0.6831 | 1 |
| 14 | DICER1 | rs3742330 | G | A | 0.0878/854 | G = 0.1382/692 | 0.2499 | 1.261 | 0.4423 | 1 |
| 14 | DICER1 | rs1057035 | C | T | 0.3709/852 | C = 0.1723/863 | 0.854 | 0.8726 | 0.4174 | 1 |
| 16 | TOX3 | rs8051542 | T | C | 0.4322/856 | T = 0.3133/1569 | 1.000 | 0.7698 | 0.1095 | 1 |
| 16 | TOX3 | rs3803662 | A | G | 0.2207/852 | A = 0.4403/2205 | 1.000 | 0.9065 | 0.6119 | 1 |
| 18 | hsa-miR-143-5p | rs4987859 | T | C | 0.0631/856 | T = 0.0477/239 | 0.597 | 0.744 | 0.3466 | 1 |
| 18 | hsa-miR-27-a-5p | rs4987852 | C | T | 0.0667/854 | C = 0.0190/95 | 0.4495 | 1.081 | 0.811 | 1 |
| 18 | hsa-miR-27-a-5p | rs1016860 | T | C | 0.1175/868 | T = 0.1166/584 | 1.000 | 0.8423 | 0.4808 | 1 |
| 21 | hsa-miR-155 HG | rs987195 | G | C | 0.0917/840 | G = 0.1472/737 | 0.361 | 0.6702 | 0.1265 | 1 |
| 21 | hsa-miR-155 | rs12482371 | C | T | 0.1632/858 | C = 0.4151/2079 | 0.5662 | 0.7506 | 0.1748 | 1 |
| X | hsa-miR-221/222 | rs34678647 | T | G | 0.0375/667 | T = 0.1423/537 | 0.1782 | 0.433 | 0.05456 | 1 |