Table 6.
Mixed model logistic regression analysis adjusted for the covariate ‘sex’ for the rs17723799 SNP in MIR143.
| Model | Genotype | Controls (%) | Cases (%) | χ2 | OR (95% CI) | p-Value |
|---|---|---|---|---|---|---|
| Allelic | T vs. C | 39/459 | 36/178 | 12.84 | - | 0.0003 |
| Additive | - | - | - | 0.43 (0.26–0.71) | 0.0009 | |
| Co-dominant | CC | 97 (71.9) | 243 (82.4) | 1.00 (reference) | ||
| CT | 35 (25.9) | 48 (16.3) | 0.55 (0.33–0.91) | |||
| TT | 3 (2.2) | 4 (1.4) | 0.47 (0.10–2.23) | 0.051 | ||
| Dominant | CC | 97 (71.9) | 243 (82.4) | 1.00 (reference) | ||
| CT–TT | 38 (28.1) | 52 (17.6) | 0.54 (0.33–0.88) | 0.015 | ||
| Recessive | CC–CT | 132 (97.8) | 291 (98.6) | 1.00 (reference) | ||
| TT | 3 (2.2) | 4 (1.4) | 0.53 (0.11–2.52) | 0.438 | ||
| Over-dominant | CC–TT | 100 (74.1) | 247 (83.7) | 1.00 (reference) | ||
| CT | 35 (25.9) | 48 (16.3) | 0.56 (0.33–0.92) | 0.024 | ||
| Log-additive | - | 135 (31.4) | 295 (68.6) | 0.58 (0.38–0.90) | 0.017 |