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. 2019 Mar 16;20(6):1336. doi: 10.3390/ijms20061336

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cilia-autophagy axis. Autophagy has an opposite effect on ciliogenesis: (A) Induction of cilia formation, by suppressing negative regulators of ciliogenesis, such as the centriolar satellite OFD1 protein, or (B) induction of cilia disassembly, by degrading proteins that are essential for ciliogenesis, such as IFT20, IFT88, and ARL13B. New molecular effectors mediating the cilia-autophagy axis are emerging. Autophagy can both repress and induce cell transformation, but whether and how autophagy influences tumorigenesis through cilia, or vice versa, requires further analysis. ARL13B: ADP ribosylation factor like GTPase 13B; IFT: intraflagellar transport; OFD1: oral-facial-digital syndrome 1.