Table 3.

Association between inflammatory markers and NIH Toolbox Performance.

	Overall Child Cognition		Flanker Inhibitory Control		Dimensional Change Card Sort		Picture Sequence Memory		Picture Vocabulary
	beta (95% CI)	p-value	beta (95% CI)	p-value	beta (95% CI)	p-value	beta (95% CI)	p-value	beta (95% CI)	p-value
IFNγ	−2.67 (–6.61, 2.48)	0.505	−5.10 (–9.95, –0.24)	0.086	−6.24 (−11.02, –1.46)	0.003	−0.39 (−4.42, 3.64)	0.874	−0.04 (−1.86,1.78)	0.972
IL-lβ	1.27 (–3.04, 5.58)	0.486	−1.08 (–5.65, 3.50)	0.699	−3.02 (–7.54, 1.50)	0.274	0.81 (−3.01, 4.63)	0.727	−0.23 (−1.93,1.48)	0.827
IL-12p70	1.69 (–2.38, 5.77)	0.688	5.20 (0.96, 9.45)	0.046	5.10 (0.91, 9.28)	0.047	0.63 (−2.97, 4.23)	0.773	0.69 (−0.89, 2.26)	0.474
IL–17A	0.01 (–3.94, 3.96)	0.986	−0.20 (–4.38, 3.98)	0.939	0.44 (–3.67, 4.56)	0.859	−1.28 (−4.78, 2.22)	0.549	−0.14 (−1.68, 1.41)	0.886
TNFα	−0.48 (–6.61, 5.64)	0.985	−5.84 (–12.40, 0.72)	0.145	−4.00 (–10.44, 2.45)	0.309	0.08 (−5.35, 5.50)	0.982	−1.76 (−4.08, 0.56)	0.214
IL-8	−4.03 (–8.86, 0.81)	0.176	−0.83 (–5.96, 4.30)	0.791	3.06 (–1.98, 8.11)	0.320	−4.77 (−9.05, −0.48)	0.069	1.57 (−0.36, 3.49)	0.183
IL-6	2.48 (–1.42, 6.37)	0.338	3.01 (–1.10, 7.13)	0.230	0.49 (–3.57, 4.54)	0.844	3.93 (0.48, 7.38)	0.063	0.20 (−1.35, 1.74)	0.836

Note: This table shows five separate regression analyses (with rows indicating predictors, and columns indicating outcomes). Each of these five separate regression models are adjusted for the following covariates: child gestational age (in weeks) and birth weight (grams), child age at assessment, maternal pre-pregnancy BMI, race/ethnicity, maternal NIH Toolbox measures, education, active smoker status, parity, delivery type, and days of blood draw. Bold values indicate statistically significant associations found at the p-value threshold < 0.05.