. 2019 Mar 19;20(6):1371. doi: 10.3390/ijms20061371

Table 1.

Phytochemicals/nutraceutical compounds modulating aquaporins (AQPs) in cancer.

Natural Compounds	Experimental Model	AQP Isoforms	Anticancer Effect	Reference
Curcumin	CaOV3	AQP3 ↓	↓ cancer cell migration	[103]
Curcumin	HeLa cells	AQP1, AQP3, AQP8, AQP11 (ND)	↓ H₂O₂	[104]
ASME, Marrubiin, Naringenin, Quercetin	HeLa cells	AQP1, AQP3, AQP8, AQP11 (ND)	↓ H₂O₂	[104]
EGCG	SKOV3	↓ AQP5	↓ proliferation ↑ apoptosis	[105]
Sulforaphane	AML cells	↓ AQP8	↓ H₂O₂ ↓ proliferation	[72]

↓: decreased; ↑ increased.