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. 2019 Apr 18;20(Suppl 4):140. doi: 10.1186/s12859-019-2682-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — General workflow for integration of proteins into a metabolic network. (1) Extraction of the informations on proteins present in metabolic reactions from a model and CellDesigner file. (2) Addition of proteins in the vicinity of catalysed reactions. (3) Merging of obtained proteins with the metabolic map through the BiNoM plugin. (4) As a result, a CellDesigner network file containing proteins on top of the original metabolic network is obtained. This file can be later integrated into NaviCell through the NaviCell Factory tool