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. 2019 Mar 19;10(3):231. doi: 10.3390/genes10030231

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The role of H3K27me3 modification in regulating gene expression in PSCs. (A) The depletion regions of H3K27me3 modification are annotated with intersection size during cell differentiation. (B) Venn diagram of 179 H3K27me3 modified DEGs between PRO and DIF cells. (C) Heatmaps of H3K27me3 modification enrichment of 179 H3K27me3 modified DEGs between ±3 kb of TSS region of two cell phases, showing the depletion of H3K27me3 marks during cell differentiation. (D) The IGV browser was used to show ChIP-Seq and RNAPII enrichment for myogenic gene, MYOG, which was released from H3K27me3 histone modification during cell differentiation. (E) Simplified model of the roles of H3K27me3 depletion in promoting cell differentiation through upregulating myogenic genes. Red points presented H3K27me3 histone modification, which showed with the scales that the peak number of H3K27me3 modification was reduced from 22,060 to 11,573 during cell differentiation.