Table 1.
Experimentally mapped linear epitopes in the structural proteins of EV-A71 and CV-A16.
| Virus | Region | Name and Position | Peptide Sequences | Epitopes | Ref. |
|---|---|---|---|---|---|
| EV-A71 | VP1 | PEP23 (aa 41–55) | TGEVPALQAAEIGAS | IgG | [25] |
| VP1–15 (aa 43–54) | KVPALQAAEIGA | IgG | [26] | ||
| VP1–14 (aa 40–51) | DTGEVPALQAAE | IgM | [26] | ||
| VP1 | PEP27 (aa 142–156) | PTGEVVPQLLQYMFV | IgM | [25] | |
| VP1 | SP55 (aa 163–177) | PESRESLAWQTATNP | IgG | [22] | |
| VP1 | SP70 (aa 208–222) | YPTFGEHKQEKDLEYC | IgM and IgG | [22] | |
| VP1 (aa 208–222) | YPTFGEHKQEKDLEYC | IgG | [24] | ||
| VP1–43 (aa 211–220) | FGEHKQEKDL | IgG | [23] | ||
| VP2 | VP2–28 (aa 136–150) | AGGTGTEDSHPPYKQ | IgG | [23] | |
| 7C7 (aa 142–146) | EDSHP | IgG | [28] | ||
| VP2 (aa 141–155) | TEDSHPPYKQTQPGA | IgG | [27] | ||
| VP4 | VP4N20 (aa 1–20) | GSQVSTQRSGSHENSNSATE | Neutralizing | [31] | |
| CV-A16 | VP1 | PEP32 (aa 94–108) | TMPTMGTQNTDGYAN | IgG | [34] |
| PEP37 (aa 109–123) | WDIDLMGYAQLRRKC | IgG | [34] | ||
| PEP55 (aa 163–177) | PTSRDSFAWQTATNP | IgG | [34] | ||
| PEP63 (aa 187–201) | PAQVSVPFMSPASAY | IgG | [34] | ||
| PEP71 (aa 211–225) | FGEHLQANDLDYGQC | IgG | [34] | ||
| PEP91 (aa 271–285) | YLFKTNPNYKGNDIK | IgG | [34] | ||
| VP3 | VP3–41 (aa 176–190) | HYRAHARAGYFDYYT | IgG | [32] | |
| VP4 | VP4N20 (aa 1–20) | GSQVSTQRSGSHENSNSASE | Neutralizing | [35] |
aa = amino acid.