Table 4.
Plasma concentrations of vitamins and metabolic markers (tHcy, Folate, Holo-TC, tCbl, MMA; mean ± SD) according to the MTHFR, TCN II, MTR and MTRR genotypes in the 17-yo group.
| 17-Year-Old | |||||
|---|---|---|---|---|---|
| SNP | tHcy (µmol/L) | Folate (nmol/L) | Holo-TC (pmol/L) | tCbl (pmol/L) | MMA (µmol/L) |
| MTHFR C677T | |||||
| CC | 8.4 ± 2.4 (n = 62) * | 11.9 ± 3.4 (n = 34) | 71.9 ± 26.3 (n = 33) | 307.6 ± 114.2 (n = 32) | 0.170 ± 0.101 (n = 55) |
| CT | 8.8 ± 3.9 (n = 48) * | 11.8 ± 5.1 (n = 34) | 63.8 ± 24.3 (n = 34) | 305.4 ± 124.2 (n = 32) | 0.175 ± 0.092 (n = 39) |
| TT | 11.3 ± 5.0 (n = 12) * | 9.0 ± 9.2 (n = 7) | 51.4 ± 19.1 (n = 7) | 250.6 ± 124.4 (n = 6) | 0.252 ± 0.161 (n = 10) |
| MTHFR A1298C | |||||
| AA | 9.4 ± 3.0 (n = 58) | 11.6 ± 4.3 (n = 35) | 69.5 ± 27.9 (n = 35) | 320.4 ± 131.6 (n = 33) | 0.190 ± 0.114 (n = 47) |
| AC | 8.5 ± 4.0 (n = 46) | 11.2 ± 3.7 (n = 25) | 63.2 ± 19.1 (n = 25) | 292.0 ± 100.7 (n = 23) | 0.162 ± 0.067 (n = 41) |
| CC | 7.9 ± 3.1 (n = 18) | 12.2 ± 4.9 (n = 15) | 63.7 ± 28.5 (n = 14) | 273.5 ± 115.9 (n = 14) | 0.197 ± 0.155 (n = 16) |
| TCN2 A67G | |||||
| AA | 8.7 ± 3.5 (n = 105) | 12.0 ± 4.4 (n = 62) | 66.2 ± 25.5 (n = 61) | 298.8 ± 119.6 (n = 58) | 0.183 ± 0.113 (n = 90) |
| AG | 10.3 ± 2.5 (n = 6) | 9.6 ± 2.6 (n = 4) | 68.1 ± 30.1 (n = 4) | 286.1 ± 71.5 (n = 4) | 0.146 ± 0.010 (n = 5) |
| GG | (n = 1) | - | - | - | (n = 1) |
| TCN2 C776G | |||||
| CC | 8.9 ± 2.4 (n = 24) | 9.6 ± 4.5 (n = 13) | 73.2 ± 28.8 (n = 13) | 292.0 ± 107.8 (n = 13) | 0.154 ± 0.073 (n = 21) |
| CG | 8.8 ± 3.2 (n = 66) | 12.5 ± 4.5 (n = 44) | 65.8 ± 25.1 (n = 44) | 314.5 ± 125.2 (n = 41) | 0.194 ± 0.128 (n = 55) |
| GG | 8.9 ± 5.0 (n = 26) | 10.4 ± 3.5 (n = 14) | 63.7 ± 24.5 (n = 13) | 279.8 ± 131.0 (n = 12) | 0.175 ± 0.074 (n = 23) |
| MTR A2756G | |||||
| AA | 8.6 ± 2.4 (n = 57) | 11.9 ± 4.5 (n = 35) | 68.7 ± 28.8 (n = 34) | 333.0 ± 126.3 (n = 31) * | 0.188 ± 0.124 (n = 50) |
| AG | 8.6 ± 2.7 (n = 38) | 11.6 ± 4.2 (n = 22) | 67.1 ± 20.8 (n = 22) | 283.1 ± 96.9 (n = 22) * | 0.165 ± 0.062 (n = 31) |
| GG | 10.1 ± 7.3 (n = 6) | 10.5 ± 3.0 (n = 5) | 61.1 ± 31.8 (n = 5) | 200.2 ± 112.3 (n = 5) * | 0.230 ± 0.193 (n = 6) |
| MTRR A66G | |||||
| AA | 8.8 ± 3.8 (n = 38) | 11.3 ± 3.9 (n = 24) | 64.3 ± 27.8 (n = 24) | 337.4 ± 138.6 (n = 22) | 0.193 ± 0.141 (n = 33) |
| AG | 8.6 ± 2.5 (n = 54) | 12.0 ± 4.7 (n = 33) | 68.9 ± 27.5 (n = 32) | 282.8 ± 110.2 (n = 31) | 0.178 ± 0.076 (n = 48) |
| GG | 8.8 ± 2.4 (n = 27) | 11.4 ± 3.8 (n = 16) | 65.6 ± 17.3 (n = 16) | 297.4 ± 106.2 (n = 15) | 0.165 ± 0.107 (n = 22) |
* p value statistically significant. p values for differences between means of the three genotypes were tested with one-way analysis of variance (ANOVA). p values < 0.05 were considered statistically significant. Significantly different plasma concentrations were found for tHcy between MTHFR 677 three genotypes (p = 0.027) and for tCbl between MTR 2756 genotypes (p = 0.041). Total Homocysteine (tHcy); total cobalamin (tCbl); holo-transcobalamin (Holo-TC); methylmalonic acid (MMA).