Table 1.
Hemodynamic and morphological data in sham and chronic heart failure (CHF) rats.
| Parameters | Sham + Vehicle (n = 6) |
Sham + Anti-BDNF (n = 6) |
CHF + Vehicle (n = 8) |
CHF + Anti-BDNF (n = 7) |
|---|---|---|---|---|
| Body weight, g | 447 ± 11 | 432 ± 12 | 462 ± 10 | 451 ± 13 |
| Heart weight, mg | 1382 ± 25 | 1334 ± 27 | 2190 ± 62 * | 2213 ± 58 * |
| HW/BW, mg/g | 3.1 ± 0.1 | 3.1 ± 0.1 | 4.7 ± 0.2 * | 4.9 ± 0.2 * |
| WLW/BW, mg/g | 4.2 ± 0.3 | 4.3 ± 0.3 | 8.7 ± 0.5 * | 9.1 ± 0.6 * |
| MAP, mmHg | 106.2 ± 3.3 | 109.3 ± 2.6 | 90.2 ± 3.6 * | 92.6 ± 3.1 * |
| HR, bpm | 362.2 ± 10.5 | 348.8 ± 15.9 | 354.3 ± 11.2 | 369.3 ± 8.3 |
| LVEDP, mmHg | 3.9 ± 0.8 | 3.2 ± 1.0 | 17.5 ± 1.5 * | 18.8 ± 1.0 * |
| EF, % | 72.5 ± 1.3 | 74.2 ± 1.4 | 43.5 ± 1.4 * | 42.3 ± 1.4 * |
| FS, % | 42.7 ± 0.7 | 43.4 ± 0.8 | 21.7 ± 0.8 * | 21.0 ± 0.8 * |
| Infarct size, % | 0 | 0 | 40.2 ± 1.8 * | 41.1 ± 1.5 * |
Values are mean ± SE. BW, body weight; HR, heart rate; HW, heart weight; MAP, mean arterial pressure; WLW, wet lung weight; LVEDP, left ventricle end-diastolic pressure; EF, ejection fraction; FS, fractional shortening. * p < 0.05 vs. sham.