Table 3.
Comparison of median Phe (μmol/L) and Tyr (μmol/L) concentrations (range) at each time point for regimens 1, 2 and 3.
| Time | R1 | R2 | R3 | |||
|---|---|---|---|---|---|---|
| Phe μmol/L | Tyr μmol/L | Phe μmol/L | Tyr μmol/L | Phe μmol/L | Tyr μmol/L | |
| 08.00 | 310 (150–490) T | 40 (30–120) | 230 (115–560) 1 | 50 (30–120) | 220 (80–440) TT | 40 (20–200) |
| 12.00 | 290 (80–450) T | 90 (40–150) | 220 (40–600) 2 | 90 (20–170) | 185 (30–480) TT | 80 (20–200) |
| 16.00 | 280 (80–500) T | 90 (30–240) § | 225 (70–670) 3 | 90 (30–220) ** | 190 (20–640) TT | 70 (30–160) §§** |
| 20.00 | 300 (80–580) T | 80 (20–190) | 210 (50–570) 4 | 75 (20–150) | 170 (20–480) TT | 80 (10–180) |
| 24.00 | 275 (30–500) T | 70 (30–150) | 185 (10–490) 5 | 85 (30–180) *** | 125 (10–440) TT | 60 (30–190) *** |
| 04.00 | 275 (50–550) T | 60 (30–110) § | 210 (70–610) 6 | 60 (30–280) **** | 150 (40–440) TT | 50 (30–100) §§**** |
Wilcoxon TvTT p < 0.0001, Tv1 p = 0.0015, Tv2 p = 0.0028, Tv3 p = 0.0016, Tv4 p = 0.0039, Tv5 p = 0.0552, Tv6 p = 0.0073, Wilcoxon test § v §§ p = 0.03, ** v** p = 0.01, *** v*** p = 0.02, **** v**** p = 0.007. Subtext symbols e.g., T,TT, **,***,**** show comparisons between the groups R1, R2 and R3.