Table 2.
Summary of reconstitution profiles of mice transplanted with Thy-1.1− Flk2+ cells
| No. of cells | Time, weeks | No.
of mice
|
Reconstitution
|
||||
|---|---|---|---|---|---|---|---|
| B+T+M | B+T | B+M | B | Mean | Range, % | ||
| 50–100* | 6 | 8/8 | 3.0 | 0.9–5.6 | |||
| 8 | 2/8 | 6/8 | 1.8 | 1.2–3.2 | |||
| 15 | 1/8 | 7/8 | 0.87 | 0.34–1.74 | |||
| 10† | 2 | 5/8 | 3/8 | ||||
| 20† | 2 | 7/8 | 1/8 | ||||
*
Mice were competitively transplanted with 50–100 Thy−, Flk-2+ cells (Lineage−/lo, c-kit+, Sca-1+). Transient donor profiles are indicated for three time points.
†
Mice were competitively transplanted with 10 or 20 Thy-Flk-2+ cells. Blood and bone marrow were assayed for B and myeloid lineages at 2 weeks posttransplant.