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. 2019 Mar 15;20(6):1322. doi: 10.3390/ijms20061322

Table 1.

Known drugs acting on IDPs (selected examples).

Compound Name * Targets Compound Structure
CLR01 (Molecular tweezers) Lysine and arginine residues in amyloid proteins graphic file with name ijms-20-01322-i001.jpg
ELN484228 α-Synuclein graphic file with name ijms-20-01322-i002.jpg
SEN1576 Amyloid β graphic file with name ijms-20-01322-i003.jpg
NQTrp PHF6 (Tau protein) graphic file with name ijms-20-01322-i004.jpg
Nutlin-3 p53-MDM2 complex graphic file with name ijms-20-01322-i005.jpg
10058-F4 c-Myc-Max complex graphic file with name ijms-20-01322-i006.jpg
10074-G5 c-Myc-Max complex graphic file with name ijms-20-01322-i007.jpg
YK-4–279 EWS-Fli1 graphic file with name ijms-20-01322-i008.jpg
Trodusquemine PTP1B graphic file with name ijms-20-01322-i009.jpg

* Unless otherwise specified, these names are directly taken from their lead-compound coding and have no meaning on their own. EWS: Ewing Sarcoma; MDM2: oncoprotein (murine double minute 2); Myc: Myelocytomatosis- transcription factor homolog; NQTrp: naphthoquinone-tryptophan hybrid; PHF6: Tau-derived peptide (amino acid sequence VQIVYK); PTP1B: protein-tyrosine phosphatase 1B.