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Plasma concentrations of choline (A) and its metabolites betaine (B) and trimethylamine oxide (TMAO) (C). Data are values of 10 adult male CF patients over 48 h prior to choline supplementation (visit 2–4 [V2–4], white symbols) and from 12 h after the end of choline supplementation (84 (84–91) days) onwards (V6–8, filled symbols). Abbreviations: ρ, Spearman rank correlation coefficient; p, significance level.
