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. 2019 Mar 18;11(3):656. doi: 10.3390/nu11030656

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kinetics of D₉-Choline and D₉-Betaine prior to (visit 2–4 [V2–4], white symbols) and from 12 h after the end of 84 (84–91) days choline supplementation (V6–8, filled symbols). CF patients (N = 10) were orally supplemented with 3 × 1 g choline chloride for 84 (84–91) d. Prior to (V2, open symbols) and 12 h after the end of supplementation (V6, filled symbols) patients were spiked orally with 3.6 mg/kg body weight [D₉-methyl]choline chloride (D₉-choline) and the kinetics of plasma D₉-choline (A) and D₉-betaine (C) concentration and of D₉-enrichment of choline (B) and betaine (D) analyzed for 48 h (V2–4 and V6–8, respectively). Data are medians and interquartile ranges from −5 min to 48 h after D₉-choline ingestion. Abbreviations: p, significance level.