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. 2019 Mar 3;11(3):106. doi: 10.3390/pharmaceutics11030106

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Rat blood and cerebrospinal fluid (CSF) geraniol concentrations (µg/mL) within 90 min after oral administration of 50 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. (B) Rat blood and CSF geraniol concentrations (µg/mL) within 90 min after oral administration of 1 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. (C) Rat blood and CSF geraniol concentrations (µg/mL) within 90 min after nasal administration of 4 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. (D) Rat blood and CSF geraniol concentrations (µg/mL) within 90 min after nasal administration of 1 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. Data are expressed as the mean ± S.D. of at least four independent experiments.

(A) Rat blood and cerebrospinal fluid (CSF) geraniol concentrations (µg/mL) within 90 min after oral administration of 50 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. (B) Rat blood and CSF geraniol concentrations (µg/mL) within 90 min after oral administration of 1 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. (C) Rat blood and CSF geraniol concentrations (µg/mL) within 90 min after nasal administration of 4 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. (D) Rat blood and CSF geraniol concentrations (µg/mL) within 90 min after nasal administration of 1 mg/kg geraniol formulated as G-CS-OA-2.0% emulsion. Data are expressed as the mean ± S.D. of at least four independent experiments.