Table 4.
Geometric mean titers and fold increase in pneumococcal immunoglobulin and opsonophagocytic antibodies after PCV-13 vaccination
| Baricitinib (N = 106) | Baseline | Week 5 | Week 12 | |
|---|---|---|---|---|
| Immunoglobulin (μg/mL) | ||||
| Serotype 4 | Geometric mean (95% CI) | 0.48 (0.41, 0.56) | 1.39 (1.05, 1.83) | 1.20 (0.91, 1.59) |
| Fold increase (95% CI) | 2.8 (2.2, 3.6)* | 2.6 (2.0, 3.2)* | ||
| Serotype 6B | Geometric mean (95% CI) | 0.89 (0.72, 1.12) | 3.32 (2.37, 4.63) | 3.10 (2.22, 4.35) |
| Fold increase (95% CI) | 3.6 (2.8, 4.5)* | 3.2 (2.6, 4.0)* | ||
| Serotype 14 | Geometric mean (95% CI) | 1.71 (1.30, 2.25) | 4.19 (3.12, 5.64) | 4.66 (3.45, 6.28) |
| Fold increase (95% CI) | 2.5 (2.0, 3.2)* | 2.5 (1.9, 3.2)* | ||
| Serotype 23F | Geometric mean (95% CI) | 0.80 (0.65, 0.99) | 2.89 (2.02, 4.14) | 2.86 (2.02, 4.05) |
| Fold increase (95% CI) | 3.5 (2.7, 4.5)* | 3.4 (2.7, 4.4)* | ||
| OI | ||||
| Serotype 4 | Geometric mean (95% CI) | 92.1 (64.8131.0) | 1717.9 (1166.0, 2531.1) | 1016.8 (688.7, 1501.1) |
| Fold increase (95% CI) | 18.2 (11.8, 28.0)* | 11.4 (7.5, 17.2)* | ||
| Serotype 6B | Geometric mean (95% CI) | 153.8 (103.1, 229.4) | 2153.0 (1431.3, 3238.7) | 1519.0 (1029.2, 2241.9) |
| Fold increase (95% CI) | 13.2 (8.5, 20.4)* | 9.0 (6.0, 13.4)* | ||
| Serotype 14 | Geometric mean (95% CI) | 270.2 (176.8, 413.1) | 1328.2 (934.2, 1888.3) | 1152.0 (811.6, 1635.2) |
| Fold increase (95% CI) | 4.9 (3.2, 7.5)* | 3.8 (2.5, 5.7)* | ||
| Serotype 23F | Geometric mean (95% CI) | 50.1 (35.1, 71.5) | 627.2 (390.5, 1007.3) | 489.3 (314.9, 760.3) |
| Fold increase (95% CI) | 12.1 (8.0, 18.5)* | 9.3 (6.3, 13.8)* | ||
*p ≤ 0.001 compared to baseline
CI confidence interval, OI opsonization index