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. 2019 Mar 14;19(5):3743–3755. doi: 10.3892/mmr.2019.10037

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Copyright: © Ni et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — β-estradiol supplement attenuates hypertension induced cytokine production in vivo. Concentrations of (A) IL-6 and (B) TNF-α in serum of WKY, SHR and SHR received β-estradiol treatment. Data are presented as the mean ± standard error of three independent experiments (n=6/group). *P<0.05 and **P<0.01 vs. the WKY group and SHR group without any drug treatment. ^#P<0.05, SHR group without any drug treatment vs. SHR group given β-estradiol. TNF-α, tumor necrosis factor-α; IL, interleukin; WKY, Wistar-Kyoto rats; SHR, spontaneously hypertensive rat; SHR + E, SHR + β-estradiol.