Table 1.
Composition of albendazole self-microemulsion chewable tablet formulations.
| Ingredients (mg/tablet) | Formulation Codes | |||
|---|---|---|---|---|
| F1 | F2 | F3 | F4 | |
| Albendazole (in microemulsion) | 40 | 40 | - | - |
| Soybean oil | - | 34 | 34 | - |
| Sesame oil | 24 | - | - | - |
| Cremophor RH40 | - | 33 | 33 | - |
| Polyethylene glycol (PEG) 400 | 38 | - | - | |
| Tween80 | 38 | 33 | 33 | - |
| Albendazole (as powder) | 160 | 160 | 200 | 200 |
| Maltodextrin | 70 | 70 | 70 | 70 |
| Mannitol | 70 | 70 | 70 | 70 |
| Colloidal silicon dioxide | 70 | 70 | 70 | 70 |
| Lactose monohydrate | 20 | 20 | 20 | 120 |
| Sucrose | 25 | 25 | 25 | 25 |
| Sodium starch glycolate | 28 | 28 | 28 | 28 |
| Milk powder | 60 | 60 | 60 | 60 |
| Coco powder | 50 | 50 | 50 | 50 |
| Vanilla powder | 0.1 | 0.1 | 0.1 | 0.1 |
| Magnesium stearate | 7 | 7 | 7 | 7 |
| Purified water * | 0.2 | 0.2 | - | 0.2 |
| Total weight | 700 | 700 | 700 | 700 |
* evaporated during manufacturing.