Table 1.

CircRNAs involved in the hallmarks of cancer

Function	CircRNA	Cancer type	expression	Associated clinical features	Associated cell process	Targets	Ref.
Sustaining growth signaling	CDR1as	NSCLC	up	TNM stage, lymph nodes metastasis and survival time	promote cell vitalities and growth, inhibit apoptosis and cell cycle arrest	miR-7/EGFR, CCNE1, PIK3CD.	[72]
	CDR1as	CRC	up	advanced tumor stage, tumor depth, and survival time	–	miR-7/EGFR, RAF1	[73]
	CDR1as	HCC	down	–	promote cell growth, adhesion, and inhibit migration	miR-7/EGFR	[74]
	circHIPK3	CRC	up	metastasis, clinical stage and survival time	inhibite cell proliferation, migration, invasion, and induce apoptosis	miR-7/EGFR, FAK, IGF1R, YY1	[75]
	hsa_circ_0046701	glioma	up	–	promote cell proliferation and invasion	miR-142-3p/ITGB8	[80]
	circ-FBXW7	glioblastoma	down	survival time	inhibit cell proliferation and cell cycle acceleration	FBXW7-185aa/c-Myc	[52]
	Circ-Amotl1	–	up	–	promote cell proliferation	c-myc	[84]
Evading growth inhibitors	circ-ITCH	Bca	down	histological grade and survival time	inhibite cell proliferation, migration, invasio, induce G1/S cell cycle arrest and apoptosis	miR-17, miR-224/p21, PTEN axis	[90]
	circ-ZFR	GC	down	–	inhibit cell propagation, cell cycle and promote apoptosis	miR-130a, miR-107/PTEN	[91]
	CDR1as	GC	up	lymph nodes metastasis and survival time	promote cell proliferation, migration and inhibit apoptosis	miR-7/PTEN/PI3K/AKT	[92]
	circRNA-000425	GC	down	–	inhibit cell growth	miR-17,miR-106/p21, BIM	[93]
	Circ100284	–	up	–	promote cell cycle acceleration	miR-217/EZH2/cyclin D1, CDK4	[97]
	hsa_circ_0016788	HCC	up	–	promote cell proliferation, invasion and inhibit apoptosis	miR-486/CDK4 axis	[98]
	circHIPK3	gallbladder cancer	up	–	promote cell survival and proliferation, inhibit cell apoptosis	miR-124/ROCK1, CDK6	[99]
Resisting apoptosis	hsa_circ_0007534	CRC	up	tumor stage and lymph node metastasis	ptomote cell proliferation and inhibit apoptosis	Bcl-2, Bax	[104]
	circUBAP2	osteosarcoma	up	tumor progression and prognosis	promote cell growth and inhibit apoptosis	miR-143/Bcl-2	[105]
	hsa_circ_0009910	osteosarcoma	up	–	promote cell proliferation inhibition, inhibit cell cycle arrest, and inhibit apoptosis	miR-449a/IL6R/Bcl-2/Bax	[106]
	hsa_circRNA_103809	CRC	down	–	promote apoptosis	miR-532-3p/FOXO4 axis	[107]
	circNFIX	glima	up	–	promote cell propagation, migration and inhibit apoptosis	miR-34a-5p/NOTCH1	[108]
	circ-DNMT1	BC	up	–	inhibit autophagy, promote cell proliferation and survival	p53, AUF1	[110]
Uncontrolled replicative immortality	has-circ-0020397	CRC	up	–	promote cell viability and inhibit apoptosis	mir-138/TERT, PD-L1	[114]
Promoting angiogenesis	circRNA-MYLK	Bca	up	pathological stage, T and N classifications and survival time	promote cell growth, angiogenesis and metastasis	miR-29a/VEGFA/VEGFR2	[118]
	cZNF292	Glima	up	–	promote cell proliferation, tube formation and angiogenic potential	VEGF-A, EGF, TGF-β1	[122]
	circHIPK3	Bca	down	tumor grade, invasion, lymph node metastasis	inhibit migration, invasion, and angiogenesis	miR-558/HPSE/VEGF	[119]
Activating invasion and metastasis	circ-10,720	HCC	up	Tumor metastasis and survival time	promote cell proliferation, migration, invasion and EMT	Vimentin	[129]
	circPTK2	NSCLC	down	–	inhibit cell invasion and EMT	miR-429, miR-200b-3p/TIF1y	[132]
	circSMAD2	HCC	down	–	inhibit cell migration, invasion, and EMT	miR-629	[137]
	hsa_circ_0061140	ovarian cancer	up	–	promote cell proliferation, migration, invasion and EMT	miR-370/FOXM1	[141]
	circ_0067934	NSCLC	up	TNM stage, lymph node statu, distant metastasis and survival time	promote cell proliferation, migration, invasion and EMT	N-cadherin, vimentin snail, and E-cadherin	[142]
	circRNA_0023642	GC	up	–	pormote cell proliferation, migration, invasion and EMT	N-cadherin, vimentin snail, and E-cadherin	[143]`