Table 2.
CircRNAs involved in stemness and chemotherapy resistance of cancer
| Function | CircRNA | Cancer type | expression | Associated clinical features | Associated cell process | Targets | Ref |
|---|---|---|---|---|---|---|---|
| Regulating stemness | circVRK1 | BC | down | – | decrease proportion of BCSCs with CD44 + CD24- phenotype, suppress BCSC’s expansion and self-renewal capacity | – | [147] |
| hg19_circ_0005033 | LSCC | up | – | promote proliferation, migration, invasion, and chemotherapy resistance of laryngeal cancer stem cells | miR-4521 | [150] | |
| Regulating chemotherapy resistance | circPVT1 | osteosarcoma | up | enneking stage, chemoresistance, lung metastasis and survival | contributes to doxorubicin and cisplatinresistance | ABCB1 | [154] |
| circRNA-MTO1 (hsa-circRNA-007874) | BC | up | – | inhibit cell viability and reverse monastrol resistance | TRAF4/Eg5 axis | [157] | |
| circBA9.3 | CML | up | – | promote resistance against TKI therapy | c-ABL1 and BCR-ABL1 | [159] |