Table 3.
CircRNAs as liquid biopsy biomarkers in cancer
| Source | Cancer type | Cohort size | CircRNA | Expression | Associated clinical features | Ref |
|---|---|---|---|---|---|---|
| saliva | OSCC | 90 OSCC patients, 70 OLK subjects | hsa_circ_0001874 | up | TNM stage, tumor grade | [165] |
| OSCC | 90 OSCC patients, 70 OLK subjects | hsa_circ_0001971 | up | TNM stage | [165] | |
| plasma | GC | 104 GC patients, 104 healthy individuals | Hsa_circ_0000190 | down | tumor diameter, lymphatic metastasis, distal metastasis, TNM stage, CA19–9levels | [163] |
| GC | 20 GC patients, 20 healthy individuals | hsa_circ_0006633 | up | distal metastasis, tissue carcinoembryonic antigen level | [167] | |
| GC | 45 GC patients, 17 healthy individuals | hsa_circ_0000520 | down | CEA expression | [168] | |
| GC | 24 GC patients, 14 healthy individuals | hsa_circ_0000673 | down | TNM stage | [169] | |
| GC | 121 GC patients, 121 healthy individuals | hsa_circ_0001017, hsa_circ_0061276 | down | OS, DFS | [170] | |
| ESCC | 30 ESCC patients, 25 healthy individuals | Circ-TTC17 | up | TNM stage, lymphatic metastasis, OS | [171] | |
| PC | 31 PC patients, 31 healthy individuals | circ-LDLRAD3 | up | CA19–9, N classification, venous invasion, lymphatic invasion | [172] | |
| BC | 57 BC patients, 17 healthy individuals | hsa_circ_0001785 | down | histological grade, TNM stage, distant metastasis | [173] | |
| HCC | 104 HCC patients, 52 healthy individuals | hsa_circ_0001445 | down | AFP level | [174] | |
| GC | 102 GC patients, 105 healthy individuals | Hsa_circ_0000181 | down | tumor differentiation, carcinoembryonic antigen | [175] | |
| LAC | 30 LAC patients, 30 healthy individuals | hsa_circ_0013958 | up | TNM stage, lymphatic metastasis | [176] | |
| serum | HCC | 64 HCC patients, 30 healthy individuals | circ-ZEB1.33 | up | TMN stages, OS | [162] |
| BCa | 197 BCa patients, 97 healthy individuals | hsa_circ_0000285 | down | tumor size, differentiation, lymph node metastasis, distant metastasis, TNM stage, OS | [177] | |
| NPC | 150 NPC patients, 100 healthy individuals | circRNA_0000285 | up | tumor size, differentiation, lymph node metastasis, distant metastasis, TNM stage. | [178] | |
| exosome (serum and urine) | UCB | 71 UCB patients, 36 healthy individuals | circPRMT5 | up | lymph node metastasis, T and N status, DFS | [166] |
| UCB | 18 UCB patients, 14 healthy individuals | circPRMT5 | up | lymph node metastasis, T and N status, DFS | [166] |