Table 3.

The F-score of the six optimal features using XGBoost with 10-fold cross-validation over 50 trials.

Rank	Feature Name	Symbol	F-Score
1	$C_{\mathsf{\alpha }}$ atom depth	RDa	0.693
2	Closeness	Closeness	0.679
3	Eccentricity	Eccentricity	0.675
4	Enrich conservation	Enrich_conserv	0.634
5	The number of $C_{\mathsf{\alpha }}$ atoms in the lower half sphere	HSEBD	0.588
6	ASA (relative total_side)	ASA_rts	0.587