Table 4.
Effect of the combination of hops compounds between them and with selected antibiotics.
| Association | FIC Index | Effect |
|---|---|---|
| XN-DMX | 0.74–1 | Additive |
| XN-Lupulone | 0.75 | Additive |
| DMX-Lupulone | 5 | Antagonist |
| CIP-XN | 0.49–1 | Synergistic to additive |
| CIP-DMX | 0.38–1.5 | Synergistic to indifferent |
| CIP-Lupulone | 0.63–1 | Additive |
| GEN-XN | 0.14–1 | Synergistic to additive |
| GEN-DMX | 0.03–0.28 | Synergistic |
| GEN-Lupulone | 9 | Antagonist |
| OXA-XN | 0.28–0.75 | Synergistic to additive |
| OXA-DMX | 0.5–0.76 | Additive |
| OXA-Lupulone | 0.19–1.25 | Synergistic to indifferent |
| RIF-XN | 0.25–0.75 | Synergistic to additive |
| RIF-DMX | 1–5 | Indifferent to antagonist |
| RIF-Lupulone | 2.2–6 | Indifferent to antagonist |
Association can be synergistic (FIC < 0.5), additive (0.5 FIC 1), indifferent (1 < FIC 4) or antagonist (FIC > 4). Ranges result from 3 independent experiments. XN: xanthohumol, DMX: desmethylxanthohumol, CIP: ciprofloxacin, GEN: gentamicin, OXA: oxacillin, RIF: rifampicin.