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IC50 of hops chalcones and acylphloroglucinols against some Trypanosoma brucei brucei and Leishmania mexicana mexicana strains.
| Parasites IC50 in µg/mL (µM) | XN | DMX | Humulone | Lupulone | SUR | PEN |
|---|---|---|---|---|---|---|
| Tbb | 2.4 ± 0.2 (6.8) | 7.7 ± 0.6 (22.6) | 10.9 ± 0.8 (30.1) | 0.9 ± 0.0 (2.2) | 0.05 (0.038) | - |
| Lmm | 6.1 ± 3.1 (17.2) | 26.2 ± 1.8 (77) | 28.8 ± 1.5 (77.9) | 4.7 ± 0.1 (11.3) | - | 0.07 (0.21) |
XN: xanthohumol, DMX: desmethylxanthohumol. Positive controls were suramin (SUR) and pentamidine (PEN). ND: Not determined.
