Table 7.
Cytotoxic activities of hops extracts and isolated compounds (chalcones and acylphloroglucinols) against WI-38, J774, Hep-G2 and MG-63 cell lines.
| Cell Lines IC50 ± SD in µg/mL (µM) | Hydro-Alcoholic Crude Extract | MC Sub-Extract | XN | DMX | Humulone | Lupulone | CAMP |
|---|---|---|---|---|---|---|---|
| WI-38 | 7.6 ± 0.1 | 5.1 ± 1.0 | 6.9 ± 0.5 (19.5) | 60.7 ± 2.5 (178.5) | 10.5 ± 2.3 (29) | 1.1 ± 0.0 (2.6) | 0.06 ± 0.0 (0.17) |
| J774 | 19.7 ± 2.8 | 11.4 ± 2.1 | 3.4 ± 0.5 (9.6) | 9.7 ± 1.0 (28.5) | 11.5 ± 0.3 (31.7) | 1.5 ± 0.1 (3.6) | 0.01 ± 0.0 (0.03) |
| Hep-G2 | 6.8 ± 2.5 | 6.5 ± 2.1 | 2.5 ± 0.8 (7.1) | 22.4 ± 2.9 (65.9) | ND | 1.2 ± 0.5 (2.9) | 0.4 ± 0.2 (1.15) |
| MG-63 | 31.4 ± 8.1 | 21.1 ± 0.4 | 10.4 ± 2.6 (29.4) | 39.5 ± 3.3 (116.2) | ND | 4.3 ± 0.4 (10.4) | 4.4 ± 1.5 (12.6) |
XN: xanthohumol, DMX: desmethylxanthohumol. Positive control was camptothecin (CAMP). ND: Not determined.