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. 2019 Apr 17;7:23. doi: 10.1186/s40560-019-0376-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Total plasma sphingosine 1-phosphate (S1P) plotted together with S1P associated with serum albumin (SA-S1P) and S1P bound to high-density lipoprotein (HDL-S1P). a S1P in patient groups in micrograms per liter and b in fractions of total plasma S1P (percent). c, d To demonstrate levels and fractions related to severity of sepsis, the cohort was adjusted according to individual SOFA scores. Groups are compared regarding to SOFA tertiles, which are generated from 100 ICU patients: Lower SOFA ≤ 3, median SOFA 4–7, and upper SOFA ≥ 8 tertile. Groups are compared using S1P concentrations in micrograms per liter (c) and in fractions of total plasma S1P (d). Data are presented as median and 95% confidence interval. Groups are compared using a non-parametric Mann-Whitney U test against control: *P < 0.05; **P < 0.01; ***P < 0.001