Table 3.
Multivariate logistic regression of HDL-S1P, SA-S1P, S1P carrier proteins (HDL and SA), and various other inflammatory markers as predictors for sepsis severity defined as septic shock or SOFA score ≥ 8
| Variable | Regression coefficient | Odds ratio (95% CI) | Significance (P value) |
|---|---|---|---|
| HDL-S1P, μg/L | − 0.146 | 0.86 (0.77–0.97) | < 0.05 |
| SA-S1P, μg/L | + 0.070 | 1.07 (0.94–1.23) | ns |
| HDL, mg/dL | − 0.320 | 0.73 (0.55–0.97) | < 0.05 |
| SA, g/L | + 0.166 | 1.18 (0.85–1.64) | ns |
| Leucocytes, ×109/L | + 0.105 | 1.11 (0.96–1.29) | ns |
| CRP, mg/L | + 0.000 | 1.00 (0.98–1.02) | ns |
| Interleukin-6, ng/L | + 0.001 | 1.00 (1.00–1.00) | ns |
| Procalcitonin, μg/L | + 0.254 | 1.29 (0.87–1.91) | ns |
S1P sphingosine 1-phosphate, HDL high-density lipoprotein, SA serum albumin, ns not significant