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. 2019 Mar 18;20(6):1354. doi: 10.3390/ijms20061354

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Venn diagram demonstrating the different number of phosphoproteins from FcGRIIb+/+ macrophages in comparison with FcGRIIb−/− after a single LPS stimulation (N/100), sequential LPS activation (100/100; LPS-tolerance), and the control (N/N) (n = 4/each group); (B) the volcano plot analysis of downregulated phosphoproteins from the sequential LPS activation of FcGRIIb−/− compared with FcGRIIb+/+ macrophages; (C) pathway analysis clusters (DAVID) of the significantly altered phosphopeptides in FcGRIIb+/+ compared with FcGRIIb−/− in LPS-tolerance (100/100); (D) GO annotation of differentially expressed proteins (FcGRIIb+/+ compared with FcGRIIb−/−) in biological processes; and (E) the enrich pathway of the phosphoproteome of FcGRIIb+/+ compared with FcGRIIb−/− was related to the phagocytosis pathway that MPHIm, Akt, PKC, SPHK, PAK1, Vav, and DOCK180 (in black star) were the proteins involved in this pathway.

(A) Venn diagram demonstrating the different number of phosphoproteins from FcGRIIb+/+ macrophages in comparison with FcGRIIb−/− after a single LPS stimulation (N/100), sequential LPS activation (100/100; LPS-tolerance), and the control (N/N) (n = 4/each group); (B) the volcano plot analysis of downregulated phosphoproteins from the sequential LPS activation of FcGRIIb−/− compared with FcGRIIb+/+ macrophages; (C) pathway analysis clusters (DAVID) of the significantly altered phosphopeptides in FcGRIIb+/+ compared with FcGRIIb−/− in LPS-tolerance (100/100); (D) GO annotation of differentially expressed proteins (FcGRIIb+/+ compared with FcGRIIb−/−) in biological processes; and (E) the enrich pathway of the phosphoproteome of FcGRIIb+/+ compared with FcGRIIb−/− was related to the phagocytosis pathway that MPHIm, Akt, PKC, SPHK, PAK1, Vav, and DOCK180 (in black star) were the proteins involved in this pathway.