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. 2019 Apr 17;17:37. doi: 10.1186/s12964-019-0351-5

Fig. 7.

Fig. 7

Proposed molecular mechanism for the regulation of FST by cav-1. In the absence of cav-1/caveolae, enhanced PI3K activity activates PKCζ which augments Sp1 phosphorylation, nuclear accumulation and activity. This increases Sp1 binding to the -123 bp region of the FST promoter, resulting in elevated FST transcriptional activation and protein expression