Table 2.
Antigens with differential seroreactivity in patients classified based on hospitalization, severity status and time of sample collection
| S. no | PlasmoDB_ID | ORF_fragment | Product description | MSI | p valuea,b | |
|---|---|---|---|---|---|---|
| In-patients | Out-patients | |||||
| 1 | PF3D7_0912500 | Exon 2 of 7 | Conserved Plasmodium protein, unknown function | 8142.5 | 3291.5 | 0.0010 |
| 2 | PF3D7_0412000 | Exon 1 of 1 | Conserved Plasmodium protein, unknown function | 7824.2 | 3517.4 | 0.0012 |
| 3 | PF3D7_1023100 | Exon 1 segment 4 | Dynein heavy chain, putative | 7769.7 | 3347.2 | 0.0024 |
| 4 | PF3D7_1249800 | Exon 1 segment 3 | Conserved Plasmodium protein, unknown function | 6368.7 | 2157.0 | 0.0019 |
| 5 | PF3D7_1301700 | Exon 2 of 2 | Plasmodium exported protein (hyp8), unknown function (GEXP07) | 5154.5 | 1742.9 | 0.0034 |
| 1 | PVX_083040 | Exon 2 of 2 segment 1 | Hypothetical protein, conserved | 9916.3 | 3654.6 | 0.0000 |
| 2 | PVX_099520 | Exon 3 of 8 | Ubiquitin-like protein, putative | 6774.6 | 2716.2 | 0.0001 |
| S. no | PlasmoDB_ID | ORF_fragment | Product description | MSI | p valuea,b | |
|---|---|---|---|---|---|---|
| Non-severe | Severe | |||||
| 1 | PF3D7_1036300 | Exon 1 of 1 | Merozoite surface protein (MSP3.8) | 11,334.2 | 3432.4 | 0.0168 |
| 2 | PF3D7_0407800 | Exon 1 segment 2 | Conserved Plasmodium protein, unknown function | 13,110.6 | 3767.8 | 0.0176 |
| 3 | PF3D7_1358500 | Exon 1 of 1 | Zinc finger protein, putative | 9686.6 | 2319.6 | 0.0025 |
| 4 | PF3D7_1001300 | Exon 2 of 2 | Plasmodium exported protein (PHISTa), unknown function | 9143.6 | 3848.5 | 0.0174 |
| 5 | PF3D7_1035100 | Exon 1 of 1 | Probable protein, unknown function | 8142.7 | 1980.5 | 0.0197 |
| 6 | PF3D7_1136200 | Exon 5 of 5 | Conserved Plasmodium protein, unknown function | 9915.7 | 3659.9 | 0.0111 |
| 7 | PF3D7_1417200 | Exon 1 segment 1 | NOT family protein, putative | 9811.8 | 3083.4 | 0.0133 |
| 8 | PF3D7_0511400 | Exon 1 of 1 | Conserved Plasmodium protein, unknown function | 10,704.2 | 2997.8 | 0.0212 |
| 9 | PF3D7_1002500 | Exon 1 of 3 | Conserved Plasmodium protein, unknown function | 8133.8 | 2635.9 | 0.0045 |
| 10 | PF3D7_1138400 | Exon 1 segment 4 | Guanylyl cyclase (GCalpha) | 5815.1 | 2521.4 | 0.0152 |
| 11 | PF3D7_1465800 | Exon 5 segment 2 | Dynein beta chain, putative | 5733.4 | 1942.9 | 0.0136 |
| S. no | PlasmoDB_ID | ORF_fragment | Product description | MSI | p valuea,b | |
|---|---|---|---|---|---|---|
| Peak season | Dry season | |||||
| 1 | PF3D7_0900200 | Exon 2 segment 1 | Rifin (RIF) | 4770.0 | 11,917.5 | 0.0053 |
| 2 | PF3D7_0506200 | Exon 1 of 1 | Transcription initiation factor TFiid, TATA binding protein (TBP) | 4883.8 | 10,961.1 | 0.0027 |
| 3 | PF3D7_0500800 | Exon 2 segment 1 | Mature parasite infected erythrocyte surface antigen, erythrocyte membrane protein 2 (MESA) | 3575.5 | 12,533.2 | 0.0000 |
| 4 | PF3D7_1229300 | Exon 1 of 1 | conserved Plasmodium protein, unknown function | 4564.7 | 10,429.6 | 0.0049 |
| 5 | PF3D7_1335100 | – | Merozoite surface protein 7 (MSP7) | 3391.6 | 12,143.4 | 0.0006 |
| 6 | PF3D7_1036300 | Exon 1 of 1 | Merozoite surface protein (MSP3.8) | 3930.7 | 10,821.2 | 0.0011 |
| 7 | PF3D7_0419700 | Exon 1 of 1 | Apical merozoite protein (Pf34) | 4112.4 | 9532.6 | 0.0079 |
ap value using SAM analysis, b Data shown for Pf antigens only for all comparisons, except in case of hospitalization status