Table II.
KEGG pathway analysis of differentially expressed genes in hypoxic myocardium.
| KEGG ID | Description | Gene ratio | P-value | Genes |
|---|---|---|---|---|
| hsa05130 | Pathogenic Escherichia coli infection | 12/406 | 3.09×10−5 | WAS, ACTB, TUBA4A, CTNNB1, TLR5, ARPC1B, TUBA3C, TUBA1B, TUBB4B, TUBA1C, TUBA3D and TUBA3E |
| hsa04510 | Focal adhesion | 24/406 | 2.00×10−4 | COL1A1, COL4A3, BCL2, VTN, ITGA11, ACTB, COL6A6, BIRC3, CAV2, PIK3R1, CTNNB1, COL9A2, TNC, ITGA3, JUN, MAP2K1, RAC2, VASP, ITGA10, LAMC3, SHC3, MYL7, TNN and COL9A1 |
| hsa04145 | Phagosome | 20/406 | 2.11×10−4 | C3, CYBA, MPO, CYBB, ACTB, TUBA4A, ATP6V1B1, C1R, MRC1, MSR1, SFTPD, CTSS, TUBA3C, TLR6, TUBA1B, TUBB4B, MARCO, TUBA1C, TUBA3D and TUBA3E |
| hsa04978 | Mineral absorption | 10/406 | 3.60×10−4 | FTL, ATP1B3, SLC31A1, HMOX1, MT1A, MT1X, MT2A, SLC26A9, ATP1A4 and MT1M |
| hsa04062 | Chemokine signaling pathway | 22/406 | 4.46×10−4 | JAK3, WAS, CCR2, PIK3R1, CCR1, PF4, PPBP, MAP2K1, RAC2, CCL2, CCL11, CCL17, CCL21, CXCL14, DOCK2, CCL13, CCL8, CCL26, CCL19, SHC3, NFKBIA and GNB4 |
| hsa04512 | ECM-receptor interaction | 13/406 | 4.52×10−4 | COL1A1, COL4A3, VTN, ITGA11, COL6A6, COL9A2, TNC, ITGA3, ITGA10, LAMC3, SV2C, TNN and COL9A1 |
| hsa04060 | Cytokine-cytokine receptor interaction | 30/406 | 6.49×10−4 | ACVRL1, AMH, IL10, GDF6, TNFRSF1B, CCR2, IL15RA, CCR1, BMP6, BMP8B, NGFR, TNFRSF11B, PF4, PPBP, CCL2, CCL11, CCL17, CCL21, TNFSF9, IL18RAP, CXCL14, CCL13, CCL8, CCL26, CCL19, BMP10, TNFRSF12A, IL17RB, BMP5 and CSF1 |
| hsa04610 | Complement and coagulation cascades | 12/406 | 1.10×10−3 | C3, C6, F13A1, F5, SERPIND1, C1QB, SERPINE1, BDKRB2, SERPINA5, VTN, C1R and F3 |
| hsa04974 | Protein digestion and absorption | 13/406 | 1.12×10−3 | COL1A1, COL3A1, COL4A3, COL6A6, ATP1B3, COL9A2, CPA3, XPNPEP2, KCNE3, SLC7A8, COL14A1, COL9A1 and ATP1A4 |
| hsa04210 | Apoptosis | 17/406 | 1.12×10−3 | BCL2, ACTB, BIRC3, PIK3R1, TUBA4A, CTSH, CTSC, JUN, MAP2K1, CTSS, TUBA3C, TUBA1B, GADD45G, NFKBIA, TUBA1C, TUBA3D and TUBA3E |
| hsa05142 | Chagas disease (American trypanosomiasis) | 14/406 | 1.22×10−3 | C3, C1QB, IL10, SERPINE1, BDKRB2, ACE, PIK3R1, GNA15, JUN, CCL2, TLR6, PPP2R2C, NFKBIA and GNAO1 |
| hsa04390 | Hippo signaling pathway | 18/406 | 1.76×10−3 | AMH, SERPINE1, GDF6, ACTB, DLG2, DVL1, CTNNB1, FZD2, BMP6, BMP8B, SNAI2, WNT9A, FZD1, FZD7, WNT6, PPP2R2C, BMP5 and NKD1 |
| hsa05217 | Basal cell carcinoma | 10/406 | 2.00×10−3 | DVL1, CTNNB1, FZD2, WNT9A, FZD1, FZD7, SMO, WNT6, GADD45G and HHIP |
ECM, extracellular matrix; Hsa, Homo sapiens; KEGG, Kyoto Encyclopedia of Genes and Genomes.