Table S1.

Blood biochemical test

	ALB (g/L)	SEM	ALP (U/L)	SEM	ALT (U/L)	SEM
NS	23.7	0.3	81.4	3.7	27.0	5.7
EM-DMC	24.3	0.2	76.2	6.7	28.7	5.7
Consi	23.1	0.3	82.3	10.4	27.3	4.8
EZH2si	25.6	0.3	81.6	7.9	27.7	3.2
	AST (U/L)	SEM	BUN (μmol/L)	SEM	CHOL (mmol/L)	SEM
NS	277.3	0.4	8.2	1.2	2.7	0.1
EM-DMC	261	0.6	8.3	0.8	2.4	0.2
Consi	281.3	0.4	8.7	1.4	2.4	0.1
EZH2si	263.2	0.3	9.3	1.0	2.2	0.1
	CK (U/L)	SEM	CREA (μmol/L)	SEM	GLU (U/L)	SEM
NS	497.0	73.6	5.0	1.2	3.3	0.2
EM-DMC	516.7	67.2	4.8	0.6	3.2	0.3
Consi	501.0	135.4	4.3	1.3	3.7	0.1
EZH2si	497.3	6.3	4.1	0.7	4.1	0.3
	HDL (U/L)	SEM	LDH (U/L)	SEM	LDL (mmol/L)	SEM
NS	1.1	0.1	1,679.67	277.8	0.2	0.01
EM-DMC	0.9	0.1	1,789.3	291.1	0.2	0.01
Consi	1.0	0.1	1,596.3	222.1	0.2	0.01
EZH2si	1.1	0.1	1,492.3	199.5	0.2	0.01
	TBIL (mg/dL)	SEM	TG (mmol/L)	SEM	TP (g/L)	SEM
NS	7.2	1.5	1.6	0.3	48.7	1.3
EM-DMC	7.1	1.3	1.5	0.3	50.1	1.2
Consi	7.2	1.1	1.6	0.2	51.8	2.0
EZH2si	8.0	1.2	1.7	0.2	51.7	1.8
	UA (μmol/L)	SEM	XAMY (U/L)	SEM
NS	121.7	12.1	1,797.3	43.5
EM-DMC	119.3	12.5	1,753.3	65.7
Consi	114.7	10.7	1,877.0	102.7
EZH2si	116.7	11.3	1,776.7	83.6