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. 2001 Nov 27;98(25):14571–14576. doi: 10.1073/pnas.251547298

Figure 3.

Figure 3

SEREX-defined molecules copresented with HER2 enhance p63–71 (T) peptide-specific CD8+ T cells. (a) Mice were immunized twice with plasmids encoding 147HER2 alone or with a mixture of plasmids encoding 147HER2 and Dna J-like 2 or ligase 1. Both SEREX-defined antigens enhanced the p63–71 (T) peptide-specific CD8+ T cell response. (b) Mice were immunized twice with gold particles coated with a mixture of plasmids encoding 147HER2 and Dna J-like 2 (simultaneous coating) or a mixture of particles separately coated with each plasmids (separate coating). Another group of mice were immunized with gold particles coated separately with 147HER2 or Dna J-like 2 plasmids and injected at two distant sites (separate sites). Enhanced numbers of p63–71 (T) peptide-specific CD8+ T cells were observed only in animals immunized with particles cocoated with 147HER2 and the SEREX-defined molecules. Target cells were as shown in Fig. 1. Data are mean ± SEM of three experiments.