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. 2019 Apr 18;9:6270. doi: 10.1038/s41598-019-42746-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High glucose-stimulated HMC-derived exosomes can be internalized by normal HMCs. Exosomes isolated from the culture supernatants of HG treated-HMCs were labeled with fluorescent dye PHK26 and incubated with normal HMCs for 3 h. (A) Fluorescence intensity image immediately and at 3 hr after the addition of PKH26-labeled GF-Exos (red). (B) Transmission electron microscopy illustrates C-Exos incorporated by a normal HMC (arrow). Bi and Bii: Expansion of endocytosed exosomes (arrow). (C) Transmission electron microscopy showed HG-Exos incorporated by normal HMC. C_I: HG-Exos being incorporated by a healthy HMC. C_II: Expansion of the endocytosis of HG-Exos.