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. 2019 Apr 18;5:15. doi: 10.1038/s41523-019-0109-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Ratio of ER∆7 mRNA expression and total ERalpha mRNA expression. Box plots showing ratio of ER∆7 mRNA expression and total ERalpha mRNA expression for ER+/Basal tumors (blue boxes), ER+/Luminal B tumors (orange boxes) and normal breast tissues (gray box). Ratio’s for fresh frozen (FF) samples and formalin-fixed paraffin embedded (FFPE) samples are depicted in separate boxplots. Central line in boxes represent the median value, boundaries of boxes represent the interquartile range and ends of whiskers represent the minimum and maximum values. P-values are obtained using the Mann-Whitney test. a Box plots for all ER+/Basal and ER+/Luminal B tumors. b Box plots for subgroup of ER+/Basal and ER+/Luminal B tumors with ER-positivity of ≥10% by immunohistochemistry